Cell+Division\Mitosis

Chapter 12  · Chromatin  - Uncoiled thin DNA fibers  · Chromosome  - DNA molecule  · Sister Chromatids  - Identical copies of the chromosome's DNA molecule  · Cetromere <span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Narrow "waist" <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Mitotic Spindle <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Forms in the cytoplasm during prophase <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Kinetochore <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Specialized region on the centromere that links each sister chromatid to the mitotic spindle <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Metaphase Plate <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Centromeres of the duplicated chromosomes are on a plane midway between the 2 poles <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Somatic Cells <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Human body cells <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Gametes <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Egg or sperm cells <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Mitosis <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Division of the nucleus <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Cytokinesis <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Division of the cytoplasm <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · G1 = 1st Gap <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Cell grows <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · S = DNA Synthesis <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Copies chromosomes <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · G2 = 2nd Gap <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Prepares for cell division <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Cell grows more <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Produces organelles, proteins & membranes <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Interphase (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Chromosomes duplicated (S Phase), but in the form of loosely packed chromatin fibers <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Prophase (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Chromatin fibers become more tightly coiled <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Each duplicated chromosome appears as 2 identical chromatids joined together <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Mitotic spindle fibers begin to form <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Centrosomes move away from each other, lengthening the microtubules between them <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Prometaphase (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Nuclear envelope fragments <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Bundles of microtubules extend from each pole toward the middle of the cell <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Some of the microtubules attach to the Kinetochore <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Metaphase (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Centrosomes are at opposite poles of the cell <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Chromosomes line up at the metaphase plate <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Anaphase (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Paired chromosomes of each chromosome separate, freeing the sister chromatids from each other <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Chromosome begin moving toward opposite poles of the cell ( while Kinetochore microtubules shorten) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - End of Anaphase the two poles of the cell have equivalent – and complete – collection of chromosomes <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Telophase (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Cell elongates <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 85.5pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> § Daughter nuclei form at the two poles of the cell <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Nuclear envelope reappears <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Chromatin fiber of each chromosome become less tightly coiled <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Equal division of one nucleus into 2 identical nuclei = complete <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Cytokinesis (Mitosis) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Is the division of the cytoplasm <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - In animal cells <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 85.5pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> § Cleavage furrow forms à pinches the cell in 2 <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - In plant cells <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 85.5pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> § Cell plate forms à causes 2 daughter cells <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Checkpoint <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Critical control point where stop and go – ahead signals can regulate the cycle <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Kinase <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Enzyme that takes a phosphate <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · Cyclin <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Hormone <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Cyclically fluctuates concentration <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · CDK (cyclin – dependent kinases) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Enzyme <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Only active when attached to a particular cyclin <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 27pt; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> · MPF (maturation promoting factor) <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Cyclin + CDK = MPF <span style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><span style="line-height: normal; margin-bottom: 0in; margin-left: 0.75in; margin-right: 0in; margin-top: 0in; text-indent: -9pt;"> - Required for a cell to progress from late Interphase to mitosis